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P Froguel Selected Research

Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)

1/2007Two Caucasian families with the hepatocyte nuclear factor-1alpha mutation Tyr218Cys.
3/2002The genetic abnormality in the beta cell determines the response to an oral glucose load.
2/2002Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes.
6/2001Routine mutation screening of HNF-1alpha and GCK genes in MODY diagnosis: how effective are the techniques of DHPLC and direct sequencing used in combination?
2/2001beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.
10/2000HNF1alpha controls renal glucose reabsorption in mouse and man.
4/2000Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families.
2/2000Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians.
1/2000Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients.

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P Froguel Research Topics

Disease

34Type 2 Diabetes Mellitus (MODY)
10/2016 - 01/2000
22Obesity
10/2016 - 03/2000
11Insulin Resistance
12/2013 - 08/2000
5Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2004 - 08/2001
4Morbid Obesity
03/2007 - 07/2000
4Mason-Type Diabetes
03/2002 - 02/2000
3Overweight
10/2016 - 03/2000
3Type 3 Maturity-Onset Diabetes of the Young
01/2007 - 04/2000
3Coronary Disease (Coronary Heart Disease)
01/2001 - 08/2000
2Hyperglycemia
02/2001 - 01/2001
2Type 2 Maturity-Onset Diabetes of the Young
08/2000 - 04/2000
1Pediatric Obesity
01/2009
1Multiple Hereditary Exostoses (Hereditary Multiple Exostoses)
12/2007
1Diabetes Complications
01/2007
1Wolcott-Rallison syndrome
12/2004
1Cardiovascular Diseases (Cardiovascular Disease)
07/2004
1Coronary Artery Disease (Coronary Atherosclerosis)
07/2004
1Atherosclerosis
07/2004
1Thrombosis (Thrombus)
09/2003
1Alzheimer Disease (Alzheimer's Disease)
04/2003
1Seizures (Absence Seizure)
08/2001
1Juvenile Myoclonic Epilepsy
08/2001
1Idiopathic Generalized Epilepsy
08/2001
1Absence Epilepsy (Childhood Absence Epilepsy)
08/2001
1Feeding and Eating Disorders (Eating Disorder)
12/2000
1Fanconi Syndrome (Syndrome, Fanconi)
10/2000
1Birth Weight (Birth Weights)
08/2000
1Vascular Diseases (Vascular Disease)
08/2000
1Type 1 Maturity-Onset Diabetes of the Young
04/2000
1Diabetic Nephropathies (Diabetic Nephropathy)
04/2000
1Insulinoma
03/2000

Drug/Important Bio-Agent (IBA)

9Glucose (Dextrose)FDA LinkGeneric
10/2016 - 04/2000
9Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)IBA
01/2007 - 01/2000
8Insulin (Novolin)FDA Link
12/2013 - 04/2000
8GlucokinaseIBA
11/2011 - 02/2000
6LeptinIBA
09/2001 - 03/2000
5Proteins (Proteins, Gene)FDA Link
10/2016 - 12/2000
5Transcription Factors (Transcription Factor)IBA
12/2010 - 02/2000
5Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA
09/2001 - 03/2000
4LipidsIBA
12/2013 - 08/2000
4Hormones (Hormone)IBA
06/2009 - 08/2001
4AdiponectinIBA
05/2005 - 08/2001
4Hepatocyte Nuclear FactorsIBA
06/2001 - 02/2000
3HDL CholesterolIBA
12/2013 - 01/2001
3Triglycerides (Triacylglycerol)IBA
12/2013 - 01/2001
3DNA (Deoxyribonucleic Acid)IBA
12/2013 - 05/2002
3Pro-Opiomelanocortin (Proopiomelanocortin)IBA
09/2001 - 03/2000
2Dietary Fats (Dietary Fat)IBA
10/2016 - 02/2012
2Hypoglycemic Agents (Hypoglycemics)IBA
11/2002 - 02/2001
2Leptin ReceptorsIBA
09/2001 - 08/2000
2alpha-MSHIBA
08/2001 - 07/2000
2EnzymesIBA
02/2001 - 08/2000
1Nonsense Codon (Nonsense Mutation)IBA
02/2015
1C-PeptideIBA
12/2013
1B-insulinIBA
07/2013
1Nerve Growth Factors (Neurotrophins)IBA
01/2012
1Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2012
1Hepatocyte Nuclear Factor 4IBA
11/2011
1antineoplaston A10 (A 10)IBA
09/2011
1GhrelinIBA
01/2009
1Ghrelin ReceptorsIBA
01/2009
1Insulin-Like PeptidesIBA
12/2007
1zinc-binding protein (zinc binding protein)IBA
12/2007
1Carrier Proteins (Binding Protein)IBA
12/2007
1Messenger RNA (mRNA)IBA
12/2007
1Cyclin-Dependent Kinase Inhibitor p15IBA
12/2007
1Protein Glutamine gamma Glutamyltransferase 2IBA
11/2007
1ectonucleotide pyrophosphatase phosphodiesterase 1IBA
10/2007
1Pancreatic Polypeptide (Pancreatic Polypeptide (PP))IBA
03/2007
1Peptide YYIBA
03/2007
1neuropeptide Y2 receptorIBA
03/2007
1Adiponectin ReceptorsIBA
07/2005
1Orphan Nuclear ReceptorsIBA
03/2005
1Genetic Markers (Genetic Marker)IBA
11/2004
1AdipokinesIBA
07/2004
1Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA
07/2004
1Plasminogen Activator Inhibitor 1IBA
09/2003
1Plasminogen Activators (Plasminogen Activator)IBA
09/2003
1JNK Mitogen-Activated Protein KinasesIBA
04/2003
1Sulfonylurea ReceptorsIBA
06/2002
1UrocortinsIBA
02/2002
1Immunoglobulin E (IgE)IBA
08/2001
1Agouti-Related ProteinIBA
08/2001
1MelanocortinsIBA
08/2001
1Amino AcidsFDA Link
08/2001
1Type 3 Melanocortin ReceptorIBA
06/2001
1Activins (Activin)IBA
05/2001
1beta-3 Adrenergic ReceptorsIBA
12/2000
1PPAR alphaIBA
11/2000
1Homeodomain Proteins (Proteins, Homeobox)IBA
10/2000
1AntioxidantsIBA
08/2000
1Aryldialkylphosphatase (Paraoxonase)IBA
08/2000
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
07/2000
1von Willebrand FactorIBA
04/2000
1Adrenergic Receptors (Adrenergic Receptor)IBA
03/2000
1PPAR gammaIBA
03/2000
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
03/2000
1Protein Isoforms (Isoforms)IBA
03/2000
1Antisense RNA (Anti-Sense RNA)IBA
03/2000

Therapy/Procedure

2Therapeutics
12/2000 - 03/2000